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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-RJR-2403 hemioxalate
RJR-2403 hemioxalate

Chemical Structure : RJR-2403 hemioxalate

CAS No.:

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RJR-2403 hemioxalate (Rivanicline hemioxalate;Metanicotine hemioxalate;RJR 2403 hemioxalate;RJR2403 hemioxalate)

货号: PC-43406Not For Human Use, Lab Use Only.

RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors.

规格 价格 库存 数量
10 mg ￥1080 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg ￥5680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors; RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes with EC50 of 732 nM; significantly improves passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats, also demonstrates greatly reduced cardiovascular effects; exerts its antinociceptive effect via nicotinic rather than either opioid or muscarinic mechanisms.

物理化学性质&存储条件

分子量 207.23
分子式 C11H15N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine hemioxalate

参考文献

1. Bencherif M, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.

2. Lippiello PM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.

3. Damaj MI, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.

4. Ueno K, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):95-100.

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