RIPK2 inhibitor OD36 |CAS:1638644-62-8 Probechem Biochemicals

Chemical Structure : RIPK2 inhibitor OD36

CAS No.: 1638644-62-8

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RIPK2 inhibitor OD36 (OD36)

货号: PC-36066Not For Human Use, Lab Use Only.

RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2.

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2 mg	￥2580	In stock
5 mg	￥4980	In stock
10 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2。
RIPK2 inhibitor OD36 inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes。
RIPK2 inhibitor OD36 reduces cellular infiltration in an in vivo MDP-induced peritonitis model。
RIPK2 inhibitor OD36 also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.

物理化学性质&存储条件

分子量	330.772
分子式	C16H15ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(13Z,14E)-25-chloro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane

参考文献

1. Tigno-Aranjuez JT, et al. J Biol Chem. 2014 Oct 24;289(43):29651-64.

2. Asquith CRM, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01213.

RIPK2 inhibitor OD36 (OD36)

生物&药学活性

物理化学性质&存储条件

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RIPK2 inhibitor OD36 (OD36)

生物&药学活性

物理化学性质&存储条件

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