RIPK2 inhibitor 8 |CAS 2141969-56-2 Probechem Biochemicals

Chemical Structure : RIPK2 inhibitor 8

CAS No.: 2141969-56-2

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RIPK2 inhibitor 8 (RIPK2-IN-8)

货号: PC-60160Not For Human Use, Lab Use Only.

RIPK2 inhibitor 8 is a potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

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10 mg	￥5580	In stock
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生物&药学活性

RIPK2 inhibitor 8 is a potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
RIPK2 inhibitor 8 displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel.
RIPK2 inhibitor 8 effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM.
RIPK2 inhibitor 8 significantly reverses MDP-induced pro-inflammatory cytokines in rat colon

物理化学性质&存储条件

分子量	392.449
分子式	C18H21FN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine

参考文献

1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.

RIPK2 inhibitor 8 (RIPK2-IN-8)

生物&药学活性

物理化学性质&存储条件

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RIPK2 inhibitor 8 (RIPK2-IN-8)

生物&药学活性

物理化学性质&存储条件

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