RIPGBM |CAS:355406-76-7 Probechem Biochemicals

Chemical Structure : RIPGBM

CAS No.: 355406-76-7

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RIPGBM (RIPK2 inhibitor RIPGBM)

货号: PC-36132Not For Human Use, Lab Use Only.

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).

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25 mg	￥1880	In stock
100 mg	￥3980	In stock
200 mg	￥5580	In stock
1 g		Get quote

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生物&药学活性

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).
RIPGBM is converted to an apoptosis-inducing derivative (cRIPGBM/RIPGBM-18) selectively in GBM CSCs.
cRIPGBM induces apoptosis in GBM CSCs by interacting with RIPK2.
RIPGBM significantly suppress tumor formation in vivo in orthotopic intracranial GBM CSC tumor xenograft mouse model.

物理化学性质&存储条件

分子量	428.463
分子式	C26H21FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

参考文献

1. Lucki NC, et al. Proc Natl Acad Sci U S A. 2019 Mar 7. pii: 201816626. doi: 10.1073/pnas.1816626116.

RIPGBM (RIPK2 inhibitor RIPGBM)

生物&药学活性

物理化学性质&存储条件

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RIPGBM (RIPK2 inhibitor RIPGBM)

生物&药学活性

物理化学性质&存储条件

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