RI-1 |CAS:415713-60-9 Probechem Biochemicals

Chemical Structure : RI-1

CAS No.: 415713-60-9

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RI-1 (RAD51 Inhibitor 1)

货号: PC-44335Not For Human Use, Lab Use Only.

RI-1 (RAD51 Inhibitor 1) is a cell-permeable RAD51 inhibitor with IC50 of 5-30 uM range.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

RI-1 (RAD51 Inhibitor 1) is a cell-permeable RAD51 inhibitor with IC50 of 5-30 uM range.
RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that serves as an interface between protein subunits in RAD51 filaments.
RI-1 specifically inhibits homologous recombination (HR) efficiency and sensitizes human cancer cells to mitomycin C.
RI-1 clearly enhances the effect of lomustine (CCNU) on tumor growth in a glioma xenograft model.

物理化学性质&存储条件

分子量	361.6077
分子式	C14H11Cl3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-

参考文献

1. Budke B, et al. Nucleic Acids Res. 2012 Aug;40(15):7347-57.

2. Berte N, et al. Mol Cancer Ther. 2016 Nov;15(11):2665-2678.

3. Budke B, et al. J Med Chem. 2013 Jan 10;56(1):254-63.

RI-1 (RAD51 Inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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RI-1 (RAD51 Inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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