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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Diacylglycerol Lipase (DAGL)-RHC-80267
RHC-80267

Chemical Structure : RHC-80267

CAS No.: 83654-05-1

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RHC-80267 (U57908, RHC 80267)

货号: PC-20126Not For Human Use, Lab Use Only.

RHC-80267 (U 57908) is a small molecule inhibitor of diacylglycerol lipase (DAGL) with IC50 values of 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively.

规格 价格 库存 数量
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg ￥2580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RHC-80267 (U 57908) is a small molecule inhibitor of diacylglycerol lipase (DAGL) with IC50 values of 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively.
RHC-80267 potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50=4 μM).
RHC-80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes.
RHC 80267 inhibits DGL activity (IC50 = 4 uM) from guinea pig platelet microsomes but had no effect on PLC.
RHC 80267 inhibits platelet aggregation (IC50 = 11 uM), release of arachidonic acid (AA), its metabolites, and ATP (IC50=4.5 uM) when guinea pig platelets were challenged with a low concentration of thrombin.

物理化学性质&存储条件

分子量 394.52
分子式 C20H34N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O,O'-((hexane-1,6-diylbis(azanediyl))bis(carbonyl))dicyclohexanone oxime

参考文献

1. Levasseur S, et al. Prostaglandins. 1984 May;27(5):673-82.

2. Sutherland CA, et al. J Biol Chem. 1982 Dec 10;257(23):14006-10.

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