RGFP963 | class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : RGFP963

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RGFP963 (RGFP 963)

货号: PC-20238Not For Human Use, Lab Use Only.

RGFP963 (RGFP 963) is a potent, selective class I HDAC inhibitor with IC50 of 1.51 uM, 0.75 and 0.096 uM for HDAC1, HDAC2, and HDAC3, respectively.

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生物&药学活性

RGFP963 (RGFP 963) is a potent, selective class I HDAC inhibitor with IC50 of 1.51 uM, 0.75 and 0.096 uM for HDAC1, HDAC2, and HDAC3, respectively.
RGFP963 weakly inhibits HDAC10 (IC50=10 uM), does not inhibit any other HDACs.
RGFP963 is able to cross the blood brain barrier.
RGFP963 (10 mg/kg) would be active during the consolidation window when administered after learning, exhibiting selective inhibition of HDAC1, HDAC2, and HDAC3 activity.
RGFP963 enhances consolidation of cued fear extinction.
RGFP963 induces largely distinct transcriptional profiles in the dorsal hippocampus of mature mice, enhances synaptic efficacy.
RGFP963, but not RGFP966, rescues memory in a mouse model of Alzheimer's Disease.

物理化学性质&存储条件

分子量	344.42
分子式	C21H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-aminophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide

参考文献

1. Bowers ME, et al. Learn Mem. 2015 Mar 16;22(4):225-31.

2. Rumbaugh G, et al. Neuropsychopharmacology. 2015 Sep;40(10):2307-16.

RGFP963 (RGFP 963)

生物&药学活性

物理化学性质&存储条件

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RGFP963 (RGFP 963)

生物&药学活性

物理化学性质&存储条件

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