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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-RG108
RG108

Chemical Structure : RG108

CAS No.: 48208-26-0

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RG108 (N-Phthalyl-L-tryptophan, RG 108)

货号: PC-20786Not For Human Use, Lab Use Only.

RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RG108 (N-Phthalyl-L-tryptophan) is small molecule that effectively blocks DNA methyltransferases (DNMT) in vitro (IC50=115 nM) and does not cause covalent enzyme trapping in human cell lines.
RG108 efficiently blocks DNA methylation, both in a cell-free in vitro system and in human cancer cell lines.
RG108 caused demethylation and reactivation of tumor suppressor genes, but it did not affect the methylation of centromeric satellite sequences. and dihydroartemisinin treatment synergize to trigger ferroptosis in cancer cells

物理化学性质&存储条件

分子量 334.33
分子式 C19H14N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Phthalyl-L-tryptophan

参考文献

1. Bodo Brueckner, et al. Cancer Res. 2005 Jul 15;65(14):6305-11.

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