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RG100204

Chemical Structure : RG100204

CAS No.: 2140901-88-6

RG100204 (RG 100204)

货号: PC-47092Not For Human Use, Lab Use Only.

RG100204 is a novel selective, small molecule inhibitor of the neutral solute channel Aquaporin 9 (AQP9), inhibits AQP9 water permeability (IC50=110 nM) and AQP9 glycerol permeability (IC50=76 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RG100204 is a novel selective, small molecule inhibitor of the neutral solute channel Aquaporin 9 (AQP9), inhibits AQP9 water permeability (IC50=110 nM) and AQP9 glycerol permeability (IC50=76 nM).
    RG100204 displays no inhibition of water or glycerol permeability in AQP3 expressing CHO cells, and only minor inhibition of AQP7.
    RG100204 inhibits AQP9 H2O2 permeability with similar potency and efficacy as for water and glycerol permeability.
    RG100204 effectively attenuates CLP-induced systolic cardiac dysfunction in septic mice, attenuates CLP-induced hepatocellular injury and renal dysfunction, effectively inhibits the NF-ĸB signalling pathway in the kidney.

    物理化学性质&存储条件

    分子量 446.588
    分子式 C20H26N6O2S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[[4-Ethyl-5-(1-methylethyl)-4H-1,2,4-triazol-3-yl]thio]-N-[5-[4-(1-methylethoxy)phenyl]-1,3,4-thiadiazol-2-yl]acetamide

    参考文献

    1. Mohammad S, et al. Front Immunol. 2022 Jun 14;13:900906.

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