RF036 (MMP-13i) | MMP-13 inhibitor | Probechem Biochemicals

Chemical Structure : RF036

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RF036 (MMP-13i, RF-036)

货号: PC-72450Not For Human Use, Lab Use Only.

RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).

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100 mg		Get quote

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生物&药学活性

RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM).
RF036 (MMP-13i) potently inhibits type II collagen cleavage with IC50 of 8.1 nM in in vitro type II collagen cleavage assays.
RF036 (MMP-13i) potently suppressed wild-type osteoclast formation in vitro at concentrations <100 nM.
RF036 (MMP-13i) strongly inhibited multiple myeloma viability.
RF036 (MMP-13i) treatment delayed multiple myeloma growth in immunocompetent syngeneic mouse model of multiple myeloma, inhibited multiple myeloma promotes systemic skeletal bone disease.

物理化学性质&存储条件

分子量	498.573
分子式	C25H27FN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(3-fluoro-4-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)phenyl)-N-(3-methyl-1-(methylamino)-1-oxobutan-2-yl)furan-2-carboxamide

参考文献

1. Chen Hao Lo, et al. Cancer Res. 2021 May 1;81(9):2415-2428.
2. Choi JY, et al. J. Med. Chem 2017, 60, 5816–5825.
3. Fuerst R, et al. Bioorg. Med. Chem 2018, 26, 4984–4995.

RF036 (MMP-13i, RF-036)

生物&药学活性

物理化学性质&存储条件

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RF036 (MMP-13i, RF-036)

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物理化学性质&存储条件

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