RET agonist BT44 | RET agonist | Probechem Biochemicals

Chemical Structure : RET agonist BT44

CAS No.: 924759-42-2

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RET agonist BT44 (BT44)

货号: PC-72010Not For Human Use, Lab Use Only.

RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.
BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).
BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.
BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain.

物理化学性质&存储条件

分子量	577.595
分子式	C28H27F4N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(5-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)piperazin-1-yl)(4-fluoro-2-(trifluoromethyl)phenyl)methanone

参考文献

1. Viisanen H, et al. Mol Pain. 2020 Jan-Dec;16:1744806920950866.

2. Renko JM, et al. J Parkinsons Dis. 2021;11(3):1023-1046.

RET agonist BT44 (BT44)

生物&药学活性

物理化学性质&存储条件

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RET agonist BT44 (BT44)

生物&药学活性

物理化学性质&存储条件

参考文献

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