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首页-小分子抑制剂&激动剂-Tyrosine Kinase-RET Tyrosine Kinase (c-RET)-RET-IN-23c
RET-IN-23c

Chemical Structure : RET-IN-23c

CAS No.: 2095172-11-3

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RET-IN-23c

货号: PC-62829Not For Human Use, Lab Use Only.

RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR.
    RET-IN-23c inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT.
    RET-IN-23c exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM.

    物理化学性质&存储条件

    分子量 288.311
    分子式 C13H16N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)isoxazol-5-yl)ethan-1-ol

    参考文献

    1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548.

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