REP8839 | MetRS inhibitor | Probechem Biochemicals

Chemical Structure : REP8839

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REP8839 (Bederocin)

货号: PC-23524Not For Human Use, Lab Use Only.

REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.

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生物&药学活性

REP8839 (Bederocin) is a potent inhibitor of S. aureus methionyl-tRNA synthetase (MetRS) with IC50 of <1.9 nM.
REP8839 also inhibits two gram-negative homologs of S. aureus MetS, H. influenzae MetG and E. coli MetG, albeit with at least 13-fold- and 160-fold-lower potency, respectively.
REP8839 exerts its antibacterial activity through specific inhibition of MetS in S. aureus.
REP8839 demonstrated a dose-dependent inhibition of protein synthesis and RNA synthesis in S. pneumoniae R6, but only protein synthesis was affected in an isogenic rel mutant deficient in the stringent response.

物理化学性质&存储条件

分子量	450.37
分子式	C20H21BrFN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4(1H)-Quinolinone, 2-[[3-[[[4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl]methyl]amino]propyl]amino]-

参考文献

1. Critchley IA, et al. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.

2. Ochsner UA, et al. Antimicrob Agents Chemother. 2005 Oct;49(10):4253-62.

REP8839 (Bederocin)

生物&药学活性

物理化学性质&存储条件

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REP8839 (Bederocin)

生物&药学活性

物理化学性质&存储条件

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