RECQL5-IN-1

Chemical Structure : RECQL5-IN-1

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货号: PC-27648Not For Human Use, Lab Use Only.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RECQL5-IN-1 is a specific small molecule inhibitor of DNA helicase RECQL5, inhibits RECQL5-helicase activity and stabilizes RECQL5-RAD51 physical interaction, preferentially kills RECQL5-expressing breast cancers but not RECQL5 knockout.
RECQL5-IN-1 treatment led to the efficient sensitization of cisplatin-resistant breast cancers but not normal mammary epithelial cells.
RECQL5-IN-1 is orally effective in reducing the growth of RECQL5-expressing breast tumors (human xenograft) in NUDE-mice with no appreciable toxicity to the vital organs.

物理化学性质&存储条件

分子量	552.50
分子式	C25H18F6N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-((5-(benzylthio)-1,3,4-oxadiazol-2-yl)(phenyl)methyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

参考文献

1. Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.

RECQL5-IN-1

生物&药学活性

物理化学性质&存储条件

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RECQL5-IN-1

生物&药学活性

物理化学性质&存储条件

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