RDN2150 | ZAP-70 inhibitor | Probechem Biochemicals

Chemical Structure : RDN2150

CAS No.: 2839429-51-3

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RDN2150 (RDN 2150, RDN-2150)

货号: PC-21064Not For Human Use, Lab Use Only.

RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.

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5 mg	￥3980	In stock
10 mg	￥5980	In stock
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生物&药学活性

RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70.
RDN2150 exhibits favorable selectivity on a 97-kinase selectivity profiling using the ScanEDGE KINOMEscan assay at 1 uM.
RDN2150 (400 nM, 48h) significantly decreases the frequency of CD69+/CD4+ T cells from 21.3 to 10.8% on CD4+ T cells stimulated by anti-CD3 plus anti-CD28 antibodies.
RDN2150 selectively inhibits CD4+ T cell activation, inhibits the secretion of IFN-γ and IL-17A in the culture supernatant of activated CD4+ T cells, effectively suppresses the phosphorylation of LAT induced by anti-CD3/CD28 stimulation.
RDN2150 ameliorates murine psoriatic skin lesions in the IMQ-induced psoriasis mouse model.

物理化学性质&存储条件

分子量	577.04
分子式	C28H29ClN8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((3-acrylamido-4-chlorobenzyl)amino)-7-((3-methoxy-4-morpholinophenyl)amino)imidazo[1,2-c]pyrimidine-8-carboxamide

参考文献

1. Danni Rao, et al. J Med Chem. 2023 Aug 18. doi: 10.1021/acs.jmedchem.3c00606.

RDN2150 (RDN 2150, RDN-2150)

生物&药学活性

物理化学性质&存储条件

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RDN2150 (RDN 2150, RDN-2150)

生物&药学活性

物理化学性质&存储条件

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