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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-RDN009
RDN009

Chemical Structure : RDN009

CAS No.: 2839429-24-0

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RDN009 (RDN-009)

货号: PC-72472Not For Human Use, Lab Use Only.

RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.

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2 mg ￥2280 In stock
5 mg ￥3680 In stock
10 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM.
RDN009 showed good selectivity for ZAP-70 over structurally related Syk (IC50>1,000 nM).
RDN009 displayed potent inhibitory effects on T cell proliferation, activation, and inflammatory cytokine production.
RDN009 demonstrated covalent linkage to ZAP-70 protein at C346.
RDN009 is a potent and selective probe of ZAP-70 for further development for treatment of autoimmune diseases.

物理化学性质&存储条件

分子量 509.951
分子式 C24H24ClN7O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((3-(2-chloroacetamido)benzyl)amino)-7-((3,5-dimethoxyphenyl)amino)imidazo[1,2-c]pyrimidine-8-carboxamide

参考文献

1. Danni Rao, et al. Eur J Med Chem. 2021 Jul 5;219:113393.

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