RD162 | AR antagonist | Probechem Biochemicals

Chemical Structure : RD162

CAS No.: 915087-27-3

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RD162 (RD 162;RD-162)

货号: PC-35346Not For Human Use, Lab Use Only.

RD162 is a second-generation, orally available antiandrogen that binds to androgen receptor (AR) with IC50 of 30.9 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RD162 is a second-generation, orally available antiandrogen that binds to androgen receptor (AR) with IC50 of 30.9 nM.
RD162 suppresses growth and induces apoptosis in human prostate cancer cells in vitro.
RD162 demonstrates greater relative affinity than the clinically used antiandrogen bicalutamide, reduces the efficiency of its nuclear translocation, and impairs both DNA binding to androgen response elements and recruitment of coactivators.
RD162 induces tumor regression in mouse models of castration-resistant human prostate cancer.

物理化学性质&存储条件

分子量	476.45
分子式	C22H16F4N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[7-[4-cyano-3-(trifluoromethyl)phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide

参考文献

1. Tran C, et al. Science. 2009 May 8;324(5928):787-90.

2. Makkonen H, et al. Mol Cell Endocrinol. 2011 Jan 1;331(1):57-65.

RD162 (RD 162;RD-162)

生物&药学活性

物理化学性质&存储条件

参考文献

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RD162 (RD 162;RD-162)

生物&药学活性

物理化学性质&存储条件

参考文献

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