RBS-10 | NQO1 inhibitor | Probechem Biochemicals

Chemical Structure : RBS-10

加入收藏

RBS-10 (RBS10)

货号: PC-21628Not For Human Use, Lab Use Only.

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.
RBS-10 inhibits the enzymatic activity of NQO1, againin intact cells and in vitro.
RBS-10 metabolism induces apoptosis via ROS and DNA damage in an NQO1-dependent manner and this bioactivation is indispensable for the cytotoxic outcome.

物理化学性质&存储条件

分子量	365.35
分子式	C19H15N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-methylbenzamido)phenyl)-5-nitrofuran-2-carboxamide

参考文献

1. Barbosa BM, et al. Angew Chem Int Ed Engl. 2023 Dec 28:e202316730.

RBS-10 (RBS10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RBS-10 (RBS10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.