RBP4 antagonist 59

Chemical Structure : RBP4 antagonist 59

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货号: PC-20717Not For Human Use, Lab Use Only.

RBP4 antagonist 59 is a potent, selective and orally bioavailable retinol-binding protein 4 (RBP4) antagonist with HTRF IC50 of 16 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

RBP4 antagonist 59 is a potent, selective and orally bioavailable retinol-binding protein 4 (RBP4) antagonist with HTRF IC50 of 16 nM.
RBP4 antagonist 59 does not display any off-target pharmacology at KOR or at any other target within a screening panel.
RBP4 antagonist 59 (20 mg/kg per day) reduces circulating levels of adipose-derived RBP4 in the mouse transgenic model of hepatic steatosis.
RBP4 antagonist 59 partially prevents high-fat diet-induced obesity in adi-hRBP4 mice, reduces hepatic free fatty acid and triglyceride levels in obese adi-hRBP4 mice.

物理化学性质&存储条件

分子量	417.37
分子式	C20H15F4N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N#CC1=CN2C(C=C1)=NN=C2C(N3CCC(C4=CC=CC(F)=C4C(F)(F)F)CC3)=O

参考文献

1. Christopher L Cioffi, et al. J Med Chem. 2019 Jun 13;62(11):5470-5500.