Atamparib (RBN-2397) | PARP7 inhibitor | Probechem Biochemicals

Chemical Structure : RBN-2397

CAS No.: 2381037-82-5

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RBN-2397 (Atamparib, RBN2397)

货号: PC-72334Not For Human Use, Lab Use Only.

RBN-2397 (Atamparib, RBN2397) is a potent, selective, orally active NAD+ competitive inhibitor of PARP7 with IC50 of <3 nM and Kd of <1 nM.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RBN-2397 (Atamparib, RBN2397) is a potent, selective, orally active NAD+ competitive inhibitor of PARP7 with IC50 of <3 nM and Kd of <1 nM.
RBN-2397 restores cytosolic nucleic acid sensing and blocks cell proliferation in a human lung cancer cell line.
BN-2397 causes complete regressions in human NSCLC NCI-H1373 xenografts and dose-dependent pharmacodynamic effects. RBN-2397 induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses.

物理化学性质&存储条件

分子量	523.44
分子式	C20H23F6N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one

参考文献

1. Joseph M Gozgit, et al. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10.

RBN-2397 (Atamparib, RBN2397)

生物&药学活性

物理化学性质&存储条件

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询单

RBN-2397 (Atamparib, RBN2397)

生物&药学活性

物理化学性质&存储条件

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