RBI2 | Ribosome biogenesis inhibitor | Probechem Biochemicals

Chemical Structure : RBI2

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RBI2 (Ribosome biogenesis inhibitor 2)

货号: PC-20939Not For Human Use, Lab Use Only.

RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.

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生物&药学活性

RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM.
RBI2 inhibits cell growth and proliferation in cell viability assays in A375 cells (IC50=680 nM), with limited effect of on the proliferation of our non-cancer cell control, HUVECs.
RBI2 inhibits anchorage independent and clonogenic growth.
RBI2 inhibits rRNA synthesis differently from other previously described ribosome biogenesis inhibitors, potentially acting through a novel pathway that upregulates the turnover of premature rRNAs.

物理化学性质&存储条件

分子量	459.52
分子式	C24H21N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)C(C#N)C(C1=C(O)N(C2=NC(C3=CC=C(OC)C=C3)=CS2)N=C1C)C4=CC=CC=C4

参考文献

1. Catherine E Scull, et al. Biochem J. 2019 Aug 9;476(15):2209-2219.

RBI2 (Ribosome biogenesis inhibitor 2)

生物&药学活性

物理化学性质&存储条件

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RBI2 (Ribosome biogenesis inhibitor 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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