RBF197 | eIF4A inhibitor | Probechem Biochemicals

Chemical Structure : RBF197

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RBF197 (RBF-197)

货号: PC-49309Not For Human Use, Lab Use Only.

RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM.

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生物&药学活性

RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM.
RBF197 potentially binds to the same pockets as Rocaglamide A (RocA).
RBF197 blocks cell proliferation against a panel of DLBCL cell lines using WST-1 assay (OCILy3 cell, IC50=0.4 uM), including SUDHL2 cell (IC50=3.2 uM), which harbors a mutation in A20, SOCS1, and TP53.
RBF197 decreases overall translation and eIF4A1 dependent pathway proteins in double-hit lymphoma.
RBF197 (1 uM and 3 uM) decreases protein levels of eIF4A, but not eIF4E1 and the transcript levels of eIF4A1, in DLBCLs RC (GCB, Double-Hit) and OCI-LY3 (ABC) cell lines.

物理化学性质&存储条件

分子量	455.457
分子式	C17H17N11O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-(1-(2-hydroxyphenyl)ethylidene)-5-(((4-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1H-1,2,3-triazole-4-carbohydrazide

参考文献

1. Forum Kayastha, et al. Mol Med. 2022 Sep 4;28(1):101.

RBF197 (RBF-197)

生物&药学活性

物理化学性质&存储条件

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RBF197 (RBF-197)

生物&药学活性

物理化学性质&存储条件

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