RB-011 | 14-3-3 inhibitor | Probechem Biochemicals

Chemical Structure : RB-011

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RB-011 (RB011, RB11)

货号: PC-61238Not For Human Use, Lab Use Only.

RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.

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生物&药学活性

RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
RB-011 has ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo.
RB-011 exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.

物理化学性质&存储条件

分子量	302.525
分子式	C21H36N+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-1-(4-octylphenethyl)pyrrolidin-1-ium

参考文献

1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36.

2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74.

RB-011 (RB011, RB11)

生物&药学活性

物理化学性质&存储条件

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RB-011 (RB011, RB11)

生物&药学活性

物理化学性质&存储条件

参考文献

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