Leritrelvir (RAY1216) | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : RAY1216

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RAY1216 (Leritrelvir, RAY-1216)

货号: PC-22071Not For Human Use, Lab Use Only.

Leritrelvir (RAY1216) is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 8.4 nM.

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生物&药学活性

Leritrelvir (RAY1216) is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 8.4 nM.
RAY1216 displays high potency against different SARS-CoV-2 variants with EC50 of 116 nM (wild type (WT)), 80 nM (Alpha), 88 nM (Beta), 69 nM (Delta), 81 nM (Omicron BA.1), 91 nM (Omicron BA.5) and 135 nM (Omicron XBB.1.9.1).
RAY1216 (150-600 mg/kg) effectively prolonged survival of mice infected with SARS-CoV-2, significantly decreased lung viral titres.
RAY1216 possesses superior drug-target residence time, when compared with PF-07321332 (nirmatrelvir), the active antiviral component in Paxlovid.

物理化学性质&存储条件

分子量	639.72
分子式	C31H44F3N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopenta[c]pyrrole-1-carboxamide, 2-[(2S)-2-cyclohexyl-2-[(2,2,2-trifluoroacetyl)amino]acetyl]-N-[(1S)-3-(cyclopentylamino)-2,3-dioxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]octahydro-, (1S,3aR,6aS)-

参考文献

1. Chen X, et al. Nat Microbiol. 2024 Apr;9(4):1075-1088.

RAY1216 (Leritrelvir, RAY-1216)

生物&药学活性

物理化学性质&存储条件

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RAY1216 (Leritrelvir, RAY-1216)

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物理化学性质&存储条件

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