RAMX3 |CAS:1397708-94-9 Probechem Biochemicals

Chemical Structure : RAMX3

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RAMX3 (RAMX-3;RAMX 3)

货号: PC-61172Not For Human Use, Lab Use Only.

RAMX3 is a tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.

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生物&药学活性

RAMX3 is a tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.
In radioligand displacement assays shows potent negative cooperativity between RAMX3 and chemokine CXCL11, providing a basis for the use of RAMX3 to investigate other potential allosteric modulators.

物理化学性质&存储条件

分子量	631.693
分子式	C33H32T3F4N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-((1-(methyl-t3)piperidin-4-yl)methyl)acetamide

参考文献

1. Bernat V, et al. ACS Chem Biol. 2014 Nov 21;9(11):2664-77.

2. Bernat V, et al. ChemMedChem. 2012 Aug;7(8):1481-9.

3. Milanos L, et al. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15277-15281.

RAMX3 (RAMX-3;RAMX 3)

生物&药学活性

物理化学性质&存储条件

参考文献

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RAMX3 (RAMX-3;RAMX 3)

生物&药学活性

物理化学性质&存储条件

参考文献

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