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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-RAF709
RAF709

Chemical Structure : RAF709

CAS No.: 1628838-42-5

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RAF709 (RAF-709, RAF 709)

货号: PC-42182Not For Human Use, Lab Use Only.

RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively.
RAF709 suppresses pERK (EC50=0.02-0.1 uM), stabilizes BRAF−CRAF dimers(EC50=0.8 uM) inhibits proliferation (EC50=0.95 uM) in KRAS mutant tumor cell lines (Calu6).
RAF709 shows effectivity in a KRAS mutant xenograft model.

物理化学性质&存储条件

分子量 542.5495
分子式 C28H29F3N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 100 mg/mL
Chemical Name/SMILES

Benzamide, N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-

参考文献

1. Nishiguchi GA, et al. J Med Chem. 2017 Jun 22;60(12):4869-4881.

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