RAF-IN-10n |CAS:950736-05-7 Probechem Biochemicals

Chemical Structure : RAF-IN-10n

CAS No.: 950736-05-7

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RAF-IN-10n

货号: PC-45437Not For Human Use, Lab Use Only.

RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.

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生物&药学活性

RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.
RAF-IN-10n displays moderate selectivity over p38α (IC50=216 nM) and CAMKII (IC50=822 nM), high selectivity over CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50>2 uM).

物理化学性质&存储条件

分子量	515.529
分子式	C29H24F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 53 mg/mL
Chemical Name/SMILES	Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)-

参考文献

1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.

RAF-IN-10n

生物&药学活性

物理化学性质&存储条件

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RAF-IN-10n

生物&药学活性

物理化学性质&存储条件

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