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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-RA839
RA839

Chemical Structure : RA839

CAS No.: 1832713-02-6

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RA839 (RA-839, RA 839)

货号: PC-60871Not For Human Use, Lab Use Only.

RA839 is a noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RA839 is a noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling.
RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM.
RA839 prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages.
RA839 acutely induces Nrf2 target gene expression in liver in mice.

物理化学性质&存储条件

分子量 452.569
分子式 C25H28N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S)-1-[4-[(2,3,5,6-tetramethylphenyl) sulfonylamino]-1-naphthyl]pyrrolidine-3-carboxylic acid

参考文献

1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55.

2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529.

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