RA608 | CaMKII inhibitor | Probechem Biochemicals

Chemical Structure : RA608

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RA608 (RA-608, RA 608)

货号: PC-72970Not For Human Use, Lab Use Only.

RA608 (RA-608) is a potent, selective, ATP-competitive, orally available CaMKII inhibitor, inhibits human CaMKIIδ, CaMKIIɣ, CaMKIIα, and CaMKIIβ with IC50 of 22, 51, 121, and 1135 nM, respectively.

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生物&药学活性

RA608 (RA-608) is a potent, selective, ATP-competitive, orally available CaMKII inhibitor, inhibits human CaMKIIδ, CaMKIIγ, CaMKIIα, and CaMKIIβ with IC50 of 22, 51, 121, and 1135 nM, respectively.
RA608 displays a good selectivity profile against a broad panel of 304 human recombinant kinases.
RA608 significantly reduces SR Ca leak in human atrial cardiomyocytes, reduces diastolic tension of human atrial trabeculae, does not affect action potential characteristics; attenuates heart failure in the murine HF model induced by TAC.

物理化学性质&存储条件

分子量	539.695
分子式	C28H37N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((4-(4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)piperidin-1-yl)-2-methoxyphenyl)amino)-7-ethoxythieno[3,2-d]pyrimidin-6-yl)propan-2-ol

参考文献

1. Julian Mustroph, et al. ESC Heart Fail. 2020 Oct;7(5):2871-2883.

RA608 (RA-608, RA 608)

生物&药学活性

物理化学性质&存储条件

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RA608 (RA-608, RA 608)

生物&药学活性

物理化学性质&存储条件

参考文献

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