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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-RA475
RA475

Chemical Structure : RA475

CAS No.: 2750008-05-8

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RA475 (RA-475)

货号: PC-22710Not For Human Use, Lab Use Only.

RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells.
RA475 cytotoxicity is mildly synergistic with cisplatin
RA475 (0.5 μM and 1 μM) induces accumulation of very high molecular weight polyubiquitinated proteins in SKOV3 cells.
RA475 stabilizes proteasome reporter protein 4UbFL in vitro and in vivo.
RA475 profoundly inhibits the intraperitoneal growth of the ID8-luciferase ovarian tumor model. 

物理化学性质&存储条件

分子量 407.48
分子式 C25H21N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-bis((E)-4-cyanobenzylidene)-2-oxo-7-azaspiro[3.5]nonane-7-carboximidamide

参考文献

1. Ravi K Anchoori, et al. PLoS One. 2024 Jul 11;19(7):e0305710.

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