RA306 | CaMKII inhibitor | Probechem Biochemicals

Chemical Structure : RA306

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RA306 (RA-306, RA 306)

货号: PC-72969Not For Human Use, Lab Use Only.

RA306 (RA-306) is a selective, potent, orally active, ATP-competitive CaMKII inhibitor, inhibits CaMKII delta (IC50=15 nM), gamma (IC50=25 nM), and alpha (IC50=61 nM) isoforms.

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生物&药学活性

RA306 (RA-306) is a selective, potent, orally active, ATP-competitive CaMKII inhibitor, inhibits CaMKII delta (IC50=15 nM), gamma (IC50=25 nM), and alpha (IC50=61 nM) isoforms.
RA306 displays a good selectivity profile vs. kinases and non-kinase targets, as compared with KN-93.
RA306 also displays a good cellular activity in cardiomyocytes from human, rat, and mice, with IC50s in the 200 nM range.
Isoproterenol-induced phosphorylation of Thr17-PLN, normalized to total PLN, was fully inhibited by RA306 in a dose-dependent manner, with IC50s of 140 nM in rat, 205 nM in mouse, and 220 nM in human cardiomyocytes.

物理化学性质&存储条件

分子量	571.737
分子式	C29H41N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2-((4-(4-(2-(hydroxymethyl)morpholino)piperidin-1-yl)-2-methoxyphenyl)amino)-7-isopropoxythieno[3,2-d]pyrimidin-6-yl)propan-2-ol

参考文献

1. Philippe Beauverger, et al. Cardiovasc Res. 2020 Feb 1;116(2):329-338.

RA306 (RA-306, RA 306)

生物&药学活性

物理化学性质&存储条件

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RA306 (RA-306, RA 306)

生物&药学活性

物理化学性质&存储条件

参考文献

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