R406 free base |CAS:841290-80-0 Probechem Biochemicals

Chemical Structure : R406 free base

CAS No.: 841290-80-0

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R406 free base (R 406;Tamatinib)

货号: PC-42815Not For Human Use, Lab Use Only.

R406 (Tamatinib) free base is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM.

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5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

R406 (Tamatinib) free base is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM.
R406 displays 5- to 100-fold selectivity over a panel of 90 kinases, no activity against Lyn kinase.
R406 does not inhibit phosphorylation of Syk tyrosine 352 but inhibited the phosphorylation of LAT tyrosine 191, inhibits the anti-IgE-induced production and release of LTC4 and cytokines and chemokines, including TNFα, IL-8, and GM-CSF.
R406 reduces immune complex-mediated inflammation in arthritis models and is orally active.

物理化学性质&存储条件

分子量	470.4536
分子式	C22H23FN6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-

参考文献

1. Braselmann S, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.

2. Cha HS, et al. J Pharmacol Exp Ther. 2006 May;317(2):571-8.

3. Matsubara S, et al. Am J Respir Crit Care Med. 2006 Jan 1;173(1):56-63.

4. Pine PR, et al. Clin Immunol. 2007 Sep;124(3):244-57.

R406 free base (R 406;Tamatinib)

生物&药学活性

物理化学性质&存储条件

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R406 free base (R 406;Tamatinib)

生物&药学活性

物理化学性质&存储条件

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