R-VK4-40 | D3R antagonist | Probechem Biochemicals

Chemical Structure : R-VK4-40

加入收藏

R-VK4-40 ((R)-VK4-40)

货号: PC-47101Not For Human Use, Lab Use Only.

R-VK4-40 is a highly selective, potent and orally available dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, >1500-dold selectivity over D2R.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

R-VK4-40 is a highly selective, potent and orally available dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, >1500-dold selectivity over D2R.
R-VK4-40 dose-dependently inhibited oxycodone self-administration and shifted oxycodone dose-response curves downward, attenuated oxycodone reward and augments analgesia in rodents.
R-VK4-40 produced mild antinociceptive effects without altering open-field locomotion or rotarod locomotor performance.
R-VK4-40 produced mild antinociceptive effects without altering open-field locomotion or rotarod locomotor performance.

物理化学性质&存储条件

分子量	454.999
分子式	C25H31ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3R)-4-[4-(2-Chloro-3-ethylphenyl)-1-piperazinyl]-3-hydroxybutyl]-1H-indole-2-carboxamide

参考文献

1. Vivek Kumar, et al. J Med Chem. 2016 Aug 25;59(16):7634-50.

2. Jordan CJ, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):602-614.

3. Jordan CJ, et al. Neuropharmacology. 2019 Nov 1;158:107597.

R-VK4-40 ((R)-VK4-40)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

R-VK4-40 ((R)-VK4-40)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.