R-7050 | TNFR inhibitor | Probechem Biochemicals

Chemical Structure : R-7050

CAS No.: 303997-35-5

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R-7050 (R7050)

货号: PC-22719Not For Human Use, Lab Use Only.

R-7050 is a specific small molecule TNF-alpha receptor (TNFR) antagonist with EC50 of 0.63 uM for TNFα-induced ICAM-1 expression inhibition, shows greater selectivity toward TNFα.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

R-7050 is a specific small molecule TNF-alpha receptor (TNFR) antagonist with EC50 of 0.63 uM for TNFα-induced ICAM-1 expression inhibition, shows greater selectivity toward TNFα.
R-7050 displays 2- to 3-fold greater than EC50 for IL-1β-induced ICAM-1 expression (1.45 μM).
R-7050 inhibits phosphorylation of both the c-Jun N-terminal kinase (JNK) pathway (MKK4, JNKs, and ATF2) and p38 pathway (MKK3/6, p38, and MAPKAP2), inhibits interaction between TNFαRI, RIP1, and TRADD.
R-7050 blocks internalization of the TNFα ligand-receptor complex. exhibited inhibitory effects only in TNFα and LPA receptor systems, but not in IL-1βR, InsulinR, IGFR, or EGFR.

物理化学性质&存储条件

分子量	380.77
分子式	C16H8ClF3N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

参考文献

1. King MD, et al. Neurosci Lett. 2013 May 10;542:92-6.

2. Gururaja TL, et al. Chem Biol. 2007 Oct;14(10):1105-18.

R-7050 (R7050)

生物&药学活性

物理化学性质&存储条件

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R-7050 (R7050)

生物&药学活性

物理化学性质&存储条件

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