R-10015 |Cas: 2097938-51-5 Probechem Biochemicals

Chemical Structure : R-10015

CAS No.: 2097938-51-5

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R-10015 (R 10015;R10015)

货号: PC-60271Not For Human Use, Lab Use Only.

R-10015 (R10015) is a potent, selective inhibitor of human LIMK1 with IC50 of 38 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

R-10015 (R10015) is a potent, selective inhibitor of human LIMK1 with IC50 of 38 nM.
R-10015 exhibits good selectivity, with off-target inhibition of only LRRK2 and p70S6K (≥90% inhibition at 1 uM) and moderate inhibition of PKA (76%), ROCK2 (70%), and FLT3 (68%).
R-10015 blocks HIV-1 viral DNA synthesis, nuclear migration, and virion release.
R-10015 has broad-spectrum antiviral effect and inhibits multiple viruses, including EBOV, RVFV, VEEV, and HSV-1.

物理化学性质&存储条件

分子量	410.86
分子式	C20H19ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl) piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate

参考文献

1. Yi F, et al. J Virol. 2017 Jun 9;91(13). pii: e02418-16.

R-10015 (R 10015;R10015)

生物&药学活性

物理化学性质&存储条件

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R-10015 (R 10015;R10015)

生物&药学活性

物理化学性质&存储条件

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