Quininib | CysLT1/CysLT2 antagonist | Probechem Biochemicals

Chemical Structure : Quininib

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Quininib (CysLT1/CysLT2 antagonist)

货号: PC-60862Not For Human Use, Lab Use Only.

Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively.
Quininib demonstrates significant anti-angiogenic activity in human endothelial cell, murine aortic ring, and murine oxygen-induced retinopathy models of angiogenesis.
Quininib does not directly target VEGFRs, and inhibits angiogenesis in a range of cell and tissue systems.

物理化学性质&存储条件

分子量	247.3
分子式	C17H13NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(E)-2-(Quinolin-2-yl)vinyl]phenol

参考文献

1. Reynolds AL, et al. J Biol Chem. 2016 Apr 1;291(14):7242-55.

2. Murphy AG, et al. Sci Rep. 2016 Oct 14;6:34523.

3. Galvin O, et al. J Control Release. 2016 Jul 10;233:198-207.

4. Butler CT, et al. J Biol Chem. 2017 Mar 3;292(9):3552-3567.