QcrB inhibitor TB47 |CAS:1799682-71-5 Probechem Biochemicals

Chemical Structure : QcrB inhibitor TB47

加入收藏

QcrB inhibitor TB47 (TB47)

货号: PC-35875Not For Human Use, Lab Use Only.

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates。
TB47 shows promising profiles, including negligible CYP450 interactions, cytotoxicity and hERG channel inhibition in pharmacokinetic and toxicity studies。
TB47 causes metabolic redox stress, strongly synergistic with pyrazinamide and rifampicin in mouse infection models, but not as a monotherapy.

物理化学性质&存储条件

分子量	538.571
分子式	C29H29F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

参考文献

1. Lu X, et al. ACS Infect Dis. 2018 Nov 28. doi: 10.1021/acsinfecdis.8b00225.

QcrB inhibitor TB47 (TB47)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

QcrB inhibitor TB47 (TB47)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.