QW-296 | Microtubule destabilizer | Probechem Biochemicals

Chemical Structure : QW-296

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QW-296 (QW296)

货号: PC-49011Not For Human Use, Lab Use Only.

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生物&药学活性

QW-296 is a novel microtubule destabilizer with little susceptible to transporter-mediated drug resistance, disturbs the microtubule dynamics at the nanomolar concentration in A375 and B16F10 melanoma cells.
QW-296 binds to colchicine-binding site on tubulin protein.
QW-296 significantly inhibited A375 and B16F10 cell proliferation, induced G2/M cell cycle arrest and led to apoptosis and cell death.
Systemic administration of QW-296 loaded nanoparticles into C57/BL6 albino mice bearing lung metastatic melanoma at the dose of 20 mg/kg 4 times a week for 1.5 weeks resulted in significant tumor regression and prolonged mouse median survival without significant change in mouse body weight.
The combination of QW-296 and MDB5 exhibited stronger anticancer activity toward DU145-TXR and PC3-TXR cells and suppressed taxane-resistant (TXR) prostate cancer colony formation when compared with single-drug treatment.

物理化学性质&存储条件

分子量	393.399
分子式	C21H19N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(4-hydroxy-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Yang R, et al. J Pharmacol Exp Ther. 2019 Sep;370(3):864-875.

2. Bariwal J, et al. J Control Release. 2019 Sep 10;309:231-243.

QW-296 (QW296)

生物&药学活性

物理化学性质&存储条件

参考文献

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QW-296 (QW296)

生物&药学活性

物理化学性质&存储条件

参考文献

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