QP5038 | QPCTL inhibitor | Probechem Biochemicals

Chemical Structure : QP5038

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QP5038 (QP 5038)

货号: PC-21630Not For Human Use, Lab Use Only.

QP5038 is a potent inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 3.8 nM, shows promising in vitro and in vivo anti-tumor efficacies.

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生物&药学活性

QP5038 is a potent inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 3.8 nM, shows promising in vitro and in vivo anti-tumor efficacies.
QP5038 shows a comparable inhibition to QPCT.
QP5038 exhibits dose-dependent inhibition of pGlu-CD47 levels in HEK293T cells with IC50 of 3.3 nM.
QP5038 significantly reduces the binding of human or mouse SIRPα protein to cell surface in HEK293T and tumor cells, blocks the binding of CD47/SIRPα.
QP5038 attenuates the interaction of CD47/SIRPα in a dose-dependent manner with an IC50 value of 8.5 nM in HEK293T cells, which is more potent than PQ912 and SEN177.
QP5038 significantly attenuates CD47 pyroglutamation in various types of cancer cells.
The anti-cancer effect of QP5038 is due to the activation of immune response.

物理化学性质&存储条件

分子量	361.42
分子式	C21H20FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-fluoropyridin-3-yl)-2-(4-(1-methyl-1H-imidazol-5-yl)piperidin-1-yl)benzonitrile

参考文献

1. Lei Yu, et al. Signal Transduct Target Ther. 2023 Dec 15;8(1):454.

QP5038 (QP 5038)

生物&药学活性

物理化学性质&存储条件

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QP5038 (QP 5038)

生物&药学活性

物理化学性质&存储条件

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