QNZ46 | GluN2C/D inhibitor | Probechem Biochemicals

Chemical Structure : QNZ46

CAS No.: 1237744-13-6

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QNZ46 (QNZ 46)

货号: PC-73198Not For Human Use, Lab Use Only.

QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively.

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10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
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生物&药学活性

QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively.
QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit.|
QNZ46 also prolongs deactivation of responses to the partial agonist NMDA in the continuous presence of glycine, prolongs receptor deactivation time.

物理化学性质&存储条件

分子量	443.42
分子式	C24H17N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(6-methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)-benzoic acid

参考文献

1. Kasper B Hansen, et al. J Neurosci. 2011 Mar 9;31(10):3650-61.

QNZ46 (QNZ 46)

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物理化学性质&存储条件

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QNZ46 (QNZ 46)

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