QM385 | Sepiapterin reductase inhibitor | Probechem Biochemicals

Chemical Structure : QM385

CAS No.: 2093421-02-2

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QM385 (QM-385, QM 385)

货号: PC-35829Not For Human Use, Lab Use Only.

QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.

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生物&药学活性

QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.
QM385 is structurally distinct from SPRi3, does not inhibit a panel of physiologically important targets or closely related reductases.
QM385 potently inhibits BH4 levels in anti-CD3/28-stimulated mouse splenocytes and human PBMCs with IC50 of 35 nM and 74 nM respectively.
QM385 treatment resulted in markedly less proliferation of CD4+ T cells in vitro, oral administration of QM385 to mice for 3 days greatly reduced the number of inflammatory T cells and eosinophils in the ovalbumin-induced and house dust mite (HDM) airway allergic inflammation models.

物理化学性质&存储条件

分子量	409.373
分子式	C17H18F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-methyl-4-(4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl)-1H-pyrazol-1-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

参考文献

1. Cronin SJF, et al. Nature. 2018 Nov;563(7732):564-568.

QM385 (QM-385, QM 385)

生物&药学活性

物理化学性质&存储条件

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QM385 (QM-385, QM 385)

生物&药学活性

物理化学性质&存储条件

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