QM31 |CAS:937735-00-7 Probechem Biochemicals

Chemical Structure : QM31

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QM31 (SVT016426;Apaf-1 inhibitor QM31)

货号: PC-35843Not For Human Use, Lab Use Only.

QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.

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生物&药学活性

QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), and caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9.
QM31 (SVT016426) suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint.
QM31 (SVT016426) can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest.

物理化学性质&存储条件

分子量	768.557
分子式	C39H38Cl4N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-2-oxoethyl)-N,1-bis(2,4-dichlorophenethyl)-4-(3,3-diphenylpropyl)-3,7-dioxo-1,4-diazepane-5-carboxamide

参考文献

1. Mondragón L, et al. Apoptosis. 2009 Feb;14(2):182-90.

2. Mondragón L, et al. J Med Chem. 2008 Feb 14;51(3):521-9.

3. Malet G, et al. Cell Death Differ. 2006 Sep;13(9):1523-32.

QM31 (SVT016426;Apaf-1 inhibitor QM31)

生物&药学活性

物理化学性质&存储条件

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QM31 (SVT016426;Apaf-1 inhibitor QM31)

生物&药学活性

物理化学性质&存储条件

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