QL-X-138

Chemical Structure : QL-X-138

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货号: PC-63076Not For Human Use, Lab Use Only.

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively.
QL-X-138 exhibits covalent binding to BTK and noncovalent binding to MNK.
QL-X-138 enhances the antiproliferative efficacies in vitro against a variety of B-cell cancer cell lines, as well as AML and CLL primary patient cells.
QL-X-138 arrests cell cycle progression and strongly induces apoptosis.

物理化学性质&存储条件

分子量	421.46
分子式	C25H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-Methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)benzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide

参考文献

1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81.

2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.

QL-X-138

生物&药学活性

物理化学性质&存储条件

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QL-X-138

生物&药学活性

物理化学性质&存储条件

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