QL-47 |CAS:1469988-75-7 Probechem Biochemicals

Chemical Structure : QL-47

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QL-47 (QL47)

货号: PC-46006Not For Human Use, Lab Use Only.

QL-47 is a potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM.

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生物&药学活性

QL-47 is a potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM.
QL-47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM.
QL-47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein in Ramos cells.
QL-47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.

物理化学性质&存储条件

分子量	447.4879
分子式	C27H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: < 9.4 mg/mL
Chemical Name/SMILES	Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)-

参考文献

1. Wu H, et al. ACS Chem Biol. 2014 May 16;9(5):1086-91.

2. Liang Y, et al. ACS Med Chem Lett. 2017 Feb 3;8(3):344-349.

3. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557.

QL-47 (QL47)

生物&药学活性

物理化学性质&存储条件

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QL-47 (QL47)

生物&药学活性

物理化学性质&存储条件

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