QL-1200186 | TYK2-JH2 inhibitor | Probechem Biochemicals

Chemical Structure : QL-1200186

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QL-1200186 (QL1200186)

货号: PC-21281Not For Human Use, Lab Use Only.

QL-1200186 is a potent, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 0.06 nM, targets pseudokinase regulatory domain (Janus homology 2, JH2) of the TYK2 protein.

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生物&药学活性

QL-1200186 is a potent, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 0.06 nM, targets pseudokinase regulatory domain (Janus homology 2, JH2) of the TYK2 protein.
QL-1200186 displays weak acitvity against JAK1 JH2 domain (IC50=9.85 nM, >160-fold), does not show inhibitory activity against TYK2 JAK1/2/3 JH1 kinases.
QL-1200186 shows dose-dependent inhibition of the JAK/STAT/ISGF3 pathway and IFNα-stimulated pSTAT5 levels in CD3+ T cells.
QL-1200186 inhibits the IL-23-induced pSTAT3 level in human Th17 cells in a dose-dependent manner.
QL-1200186 reduces IL-12/IL-18-driven IFNγ release, improves imiquimod-induced psoriasis-like skin inflammation in mice.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Celia X-J Che, et al. Cell Commun Signal. 2023 Oct 16;21(1):287.

QL-1200186 (QL1200186)

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物理化学性质&存储条件

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QL-1200186 (QL1200186)

生物&药学活性

物理化学性质&存储条件

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