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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-QGC583
QGC583

Chemical Structure : QGC583

CAS No.: 2417001-16-0

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QGC583 (QGC-583)

货号: PC-23036Not For Human Use, Lab Use Only.

QGC583 is a potent, selective aminopeptidase A (APA) with IC50 of 4 nM, >5000-fold selective over aminopeptidase N (APN).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

QGC583 is a potent, selective aminopeptidase A (APA) with IC50 of 4 nM, >5000-fold selective over aminopeptidase N (APN).
QGC583 penetrates the brain and reach brain APA after i.v. administration in rats, but also strongly inhibits renal and cardiac APA activities.

物理化学性质&存储条件

分子量 271.25
分子式 C12H18NO4P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4R)-4-amino-4-(hydroxy(phenethyl)phosphoryl)butanoic acid

参考文献

1. Balavoine F, et al. Bioorg Med Chem Lett. 2024 Sep 2:129940.

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