QD325 |CAS:2132410-88-7 Probechem Biochemicals

Chemical Structure : QD325

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QD325 (QD 325, QD-325)

货号: PC-62575Not For Human Use, Lab Use Only.

QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM).

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生物&药学活性

QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM).
QD325 induces stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells.
QD325 dose-dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3, and HSPA5, blocks mitochondrial function by inhibiting mtDNA transcription and downregulating the mtDNA-encoded OXPHOS enzymes.
QD325 is well tolerated in vivo and significantly delayes tumor growth in mice.

物理化学性质&存储条件

分子量	327.343
分子式	C20H13N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-([1,1'-biphenyl]-4-ylamino)quinazoline-5,8-dione

参考文献

1. Kuang Y, et al. J Med Chem. 2018 Feb 22;61(4):1576-1594.

QD325 (QD 325, QD-325)

生物&药学活性

物理化学性质&存储条件

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QD325 (QD 325, QD-325)

生物&药学活性

物理化学性质&存储条件

参考文献

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