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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-QD 232
QD 232

Chemical Structure : QD 232

CAS No.: 1527467-32-8

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QD 232 (QD232)

货号: PC-62576Not For Human Use, Lab Use Only.

QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration.
    QD 232 arrests cell cycle progression and induces apoptosis at low micromolar concentrations, shows effectivity in drug-resistant cancer cell lines.

    物理化学性质&存储条件

    分子量 293.282
    分子式 C16H11N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-((3-acetylphenyl)amino)quinazoline-5,8-dione

    参考文献

    1. Pathania D, et al. Br J Pharmacol. 2015 Jan;172(1):50-63.

    2. Kuang Y, et al. J Med Chem. 2018 Feb 22;61(4):1576-1594.

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