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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-Q308
Q308

Chemical Structure : Q308

CAS No.: 2700216-93-7

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Q308 (Latent HIV-1 inhibitor)

货号: PC-38556Not For Human Use, Lab Use Only.

Q308 is a small molecule that silences the latent HIV-1 provirus by inhibiting Tat-mediated gene transcription and selectively downregulates the expression levels of the facilitated chromatin transcription (FACT) complex.

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纯度 & COA & 质检文件 纯度: 98.49% (HPLC) Select Batch:

生物&药学活性

Q308 is a small molecule that silences the latent HIV-1 provirus by inhibiting Tat-mediated gene transcription and selectively downregulates the expression levels of the facilitated chromatin transcription (FACT) complex.
Q308 induced the preferential apoptosis in HIV-1 latently infected cells, Q308 may reduce the size of the viral reservoir.

物理化学性质&存储条件

分子量 301.302
分子式 C15H15N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6,7,8-trimethoxy-2-(1H-pyrrol-2-yl)quinazolin-4(3H)-one

参考文献

1. Zhou CL, et al. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0047021.

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