Q-VD-Oph |CAS:1135695-98-5 Probechem Biochemicals

Chemical Structure : Q-VD-Oph

CAS No.: 1135695-98-5

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Q-VD-Oph (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone)

货号: PC-42968Not For Human Use, Lab Use Only.

Q-VD-Oph is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM.

规格	价格	库存
5 mg	￥780	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg	￥5480	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Q-VD-Oph is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM.
Q-VD-Oph reduces doxorubicin-induced caspase-3 activation, increases expression of p21/WAF1 and senescence -associated -beta-galactosidase activity, but does not alter Akt activation.
Q-VD-Oph is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk.
Q-VD-Oph prevents activated caspase-7 and caspase-cleaved fragments of tau in the TgCRND8 brain, as well as pathology associated with TgCRND8 mice.

物理化学性质&存储条件

分子量	513.49
分子式	C26H25F2N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 25 mg/mL
Chemical Name/SMILES	Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-

参考文献

1. Caserta TM, et al. Apoptosis. 2003 Aug;8(4):345-52.

2. Rebbaa A, et al. Oncogene. 2003 May 8;22(18):2805-11.

3. Rohn TT, et al. Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.

4. Renolleau S, et al. J Neurochem. 2007 Feb;100(4):1062-71.

Q-VD-Oph (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone)

生物&药学活性

物理化学性质&存储条件

参考文献

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Q-VD-Oph (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone)

生物&药学活性

物理化学性质&存储条件

参考文献

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